Sensing-enabled hippocampal deep brain stimulation in idiopathic nonhuman primate epilepsy.
Identifieur interne : 000315 ( Main/Exploration ); précédent : 000314; suivant : 000316Sensing-enabled hippocampal deep brain stimulation in idiopathic nonhuman primate epilepsy.
Auteurs : W J Lipski [États-Unis] ; V J Destefino [États-Unis] ; S R Stanslaski [États-Unis] ; A R Antony [États-Unis] ; D J Crammond [États-Unis] ; J L Cameron [États-Unis] ; R M Richardson [États-Unis]Source :
- Journal of neurophysiology [ 1522-1598 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- physiopathologie : Hippocampe, Épilepsie généralisée.
- Animaux, Macaca mulatta, Mâle, Ondes du cerveau, Stimulation cérébrale profonde, Épilepsie généralisée.
English descriptors
- KwdEn :
- MESH :
- physiopathology : Epilepsy, Generalized, Hippocampus.
- therapy : Epilepsy, Generalized.
- Animals, Brain Waves, Deep Brain Stimulation, Macaca mulatta, Male.
Abstract
Epilepsy is a debilitating condition affecting 1% of the population worldwide. Medications fail to control seizures in at least 30% of patients, and deep brain stimulation (DBS) is a promising alternative treatment. A modified clinical DBS hardware platform was recently described (PC+S) allowing long-term recording of electrical brain activity such that effects of DBS on neural networks can be examined. This study reports the first use of this device to characterize idiopathic epilepsy and assess the effects of stimulation in a nonhuman primate (NHP). Clinical DBS electrodes were implanted in the hippocampus of an epileptic NHP bilaterally, and baseline local field potential (LFP) recordings were collected for seizure characterization with the PC+S. Real-time automatic detection of ictal events was demonstrated and validated by concurrent visual observation of seizure behavior. Seizures consisted of large-amplitude 8- to 25-Hz oscillations originating from the right hemisphere and quickly generalizing, with an average occurrence of 0.71 ± 0.15 seizures/day. Various stimulation parameters resulted in suppression of LFP activity or in seizure induction during stimulation under ketamine anesthesia. Chronic stimulation in the awake animal was studied to evaluate how seizure activity was affected by stimulation configurations that suppressed broadband LFPs in acute experiments. This is the first electrophysiological characterization of epilepsy using a next-generation clinical DBS system that offers the ability to record and analyze neural signals from a chronically implanted stimulating electrode. These results will direct further development of this technology and ultimately provide insight into therapeutic mechanisms of DBS for epilepsy.
DOI: 10.1152/jn.00619.2014
PubMed: 25429118
Affiliations:
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xml:lang="en"><term>Animals</term><term>Brain Waves</term><term>Deep Brain Stimulation</term><term>Epilepsy, Generalized (physiopathology)</term><term>Epilepsy, Generalized (therapy)</term><term>Hippocampus (physiopathology)</term><term>Macaca mulatta</term><term>Male</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Hippocampe (physiopathologie)</term><term>Macaca mulatta</term><term>Mâle</term><term>Ondes du cerveau</term><term>Stimulation cérébrale profonde</term><term>Épilepsie généralisée ()</term><term>Épilepsie généralisée (physiopathologie)</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Hippocampe</term><term>Épilepsie généralisée</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Epilepsy, Generalized</term><term>Hippocampus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Epilepsy, Generalized</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brain Waves</term><term>Deep Brain Stimulation</term><term>Macaca mulatta</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Macaca mulatta</term><term>Mâle</term><term>Ondes du cerveau</term><term>Stimulation cérébrale profonde</term><term>Épilepsie généralisée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epilepsy is a debilitating condition affecting 1% of the population worldwide. Medications fail to control seizures in at least 30% of patients, and deep brain stimulation (DBS) is a promising alternative treatment. A modified clinical DBS hardware platform was recently described (PC+S) allowing long-term recording of electrical brain activity such that effects of DBS on neural networks can be examined. This study reports the first use of this device to characterize idiopathic epilepsy and assess the effects of stimulation in a nonhuman primate (NHP). Clinical DBS electrodes were implanted in the hippocampus of an epileptic NHP bilaterally, and baseline local field potential (LFP) recordings were collected for seizure characterization with the PC+S. Real-time automatic detection of ictal events was demonstrated and validated by concurrent visual observation of seizure behavior. Seizures consisted of large-amplitude 8- to 25-Hz oscillations originating from the right hemisphere and quickly generalizing, with an average occurrence of 0.71 ± 0.15 seizures/day. Various stimulation parameters resulted in suppression of LFP activity or in seizure induction during stimulation under ketamine anesthesia. Chronic stimulation in the awake animal was studied to evaluate how seizure activity was affected by stimulation configurations that suppressed broadband LFPs in acute experiments. This is the first electrophysiological characterization of epilepsy using a next-generation clinical DBS system that offers the ability to record and analyze neural signals from a chronically implanted stimulating electrode. These results will direct further development of this technology and ultimately provide insight into therapeutic mechanisms of DBS for epilepsy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Lipski, W J" sort="Lipski, W J" uniqKey="Lipski W" first="W J" last="Lipski">W J Lipski</name></region><name sortKey="Antony, A R" sort="Antony, A R" uniqKey="Antony A" first="A R" last="Antony">A R Antony</name><name sortKey="Cameron, J L" sort="Cameron, J L" uniqKey="Cameron J" first="J L" last="Cameron">J L Cameron</name><name sortKey="Crammond, D J" sort="Crammond, D J" uniqKey="Crammond D" first="D J" last="Crammond">D J Crammond</name><name sortKey="Destefino, V J" sort="Destefino, V J" uniqKey="Destefino V" first="V J" last="Destefino">V J Destefino</name><name sortKey="Richardson, R M" sort="Richardson, R M" uniqKey="Richardson R" first="R M" last="Richardson">R M Richardson</name><name sortKey="Stanslaski, S R" sort="Stanslaski, S R" uniqKey="Stanslaski S" first="S R" last="Stanslaski">S R Stanslaski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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